We propose the A-Cube design methodology to create medical decision support on the edge. The design and implementation of an atrial fibrillation detector hardware core was selected as a proof-of-concept study. To facilitate the required atrial fibrillation functionality, we adopted an established AI model, based on Long Short-Term Memory (LSTM) technology for hardware implementation. The adaptation was done by varying design parameters such as data window and the number of LSTM units.